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Colchicine-Antigout agents
Colimax 0.6mg Tablet is used to treat and prevent gout attacks and manage symptoms of FMF, a genetic disorder causing recurrent fevers and inflammation.
Colchicine reduces uric acid crystal buildup in joints, decreasing swelling and pain in gout. In FMF, it decreases amyloid protein production, alleviating pain in the abdomen, chest, or joints.
Avoid consuming alcohol while taking Colimax 0.6mg Tablet. Consult your doctor before taking this medication.
Colimax 0.6mg Tablet is not recommended for use in pregnant women for gout management. It should only be used in cases of familial Mediterranean fever (FMF) if necessary. Women of childbearing potential should use effective contraception during and for at least three months after discontinuing Colimax 0.6mg Tablet for gout management. Consult your doctor before taking this medication.
Colimax 0.6mg Tablet is not recommended for breastfeeding women when used for gout management. For FMF, it should be used with caution and only if clearly necessary. Consult your doctor before using this medication while breastfeeding.
Colimax 0.6mg Tablet may cause drowsiness and dizziness, which can impair your ability to drive or operate machinery. Consult your doctor before taking this medication.
Colimax 0.6mg Tablet should be used with caution in patients with kidney problems, and careful monitoring by your doctor is required. It is not recommended for use in patients with severe renal impairment. Consult your doctor for advice before taking this medication.
Colimax 0.6mg Tablet should be used with caution in patients with liver problems and requires careful monitoring by your doctor. It is not recommended for use in patients with severely impaired liver disease. Consult your doctor for advice before taking this medication.
Colimax reduces inflammation which causes pain, swelling, and other symptoms of gout.
Colimax is FDA-approved to prevent and treat sudden severe gout attacks. In gout, uric acid crystals deposit in joints, prompting white blood cells to attempt to engulf them, releasing lactic acid and pro-inflammatory enzymes. This leads to the characteristic pain and swelling of gout. Colimax inhibits white blood cell migration to inflamed areas, reducing pain and inflammation.
An acute gout attack results from an inflammatory reaction to monosodium urate crystals deposited in joint tissue, exacerbated by more crystal accumulation. Leukocytes migrate to these sites, trying to engulf the crystals, releasing lactic acid and pro-inflammatory enzymes. This causes inflammation with severe pain, redness, and swelling. Colchicine inhibits the phagocytosis of uric acid by leukocytes and reduces lactic acid production, disrupting the cycle of urate crystal deposition and the inflammatory response, and alleviating the acute attack of gout.
Colchicine is orally absorbed, reaching a mean peak concentration (Cmax) of 2.5 ng/mL in 1 to 2 hours after a single dose on an empty stomach. The mean apparent volume of distribution is approximately 5 to 8 L/kg. Colchicine binds low to serum protein (39 ± 5%), primarily to albumin. It is metabolized by CYP3A4 into 2-O-demethylcolchicine and 3-O-demethylcolchicine. Plasma levels of these metabolites are minimal. Following multiple oral doses (0.6 mg twice daily), the mean elimination half-life is 26.6 to 31.2 hours.
Acute Gouty Arthritis:
Prophylaxis During Intercritical Periods:
Prophylaxis Against Attacks in Patients Undergoing Surgery:
Pediatric Use: Gout is rare in pediatric patients, and the safety and effectiveness of Colimax in this population have not been established.
Co-administration with P-gp and/or CYP3A4 inhibitors (e.g., clarithromycin or cyclosporine) alters Colimax concentration.
Not recommended for patients with renal or hepatic impairment when used with P-gp or strong CYP3A4 inhibitors (e.g., clarithromycin or cyclosporine).
Store below 30°C, protected from light and moisture. Keep out of reach of children.
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